All articles by Chandrika Kapagunta

Multiple sequence alignment studies of merA protein sequence

In the previous article, similar gene sequences of an established mercuric ion reductase or merA gene were identified. They were studied from the NCBI database using BLAST tool. In this article, the protein sequence of merA enzyme is studied with respect to its closely related sequences found in NCBI database, through Multiple Sequence Alignment (MSA). MSA refers to alignment of three or more biological sequences, protein or nucleic acid of similar length. Read more »

Epidemiology and public Health challenge from emerging infectious diseases

Infectious diseases have plagued humans before the dawn of civilisation. In the last few decades, after the discovery of penicillin, a large number of these diseases have been controlled or eliminated. However, infectious diseases have a tendency to recur in a different population or region than before. This phenomenon is termed as emerging infectious diseases (EID). Old infectious diseases re-emerge due to developed attributes like resistance or increased virulence (The Henry J Kaiser Family Foundation, 2014). One of the reasons is increased globalisation and environmental changes. This leads microbes to spread in new regions. Another reason is increasing drug resistance, making EIDs’ a grave concern (WHO Community, 2014). Read more »

Importance of bioremediation and its future prospects

Bioremediation helps cleaning up polluted environments, including soils, groundwater and marine environments. Such systems can include bacteria, fungi, algae and plant species. They are capable of metabolizing, immobilizing or absorbing toxic compounds from their environment. However, a major advantage of these systems is that they are less harmful to the environment with minimum or no by-products. Read more »

Role of serological and molecular marker analysis in emerging infectious diseases

Traditional methods of infectious disease diagnosis are Gram- staining, pathogen culturing, and study of virus morphology by inoculating culture. Conventional techniques are time consuming and lack sensitivity. Serological and molecular markers are new diagnostic approaches that offer rapid, sensitive and more accurate diagnostic results. Molecular markers are specific short sequence of DNA or RNA. Molecular markers are capable of detecting polymorphism in the specific chromosomal region associated with unique chromosomal locations, that can be random. On the other hand, serological markers are used to measure the concentrations of an antibody. These are potentially the most direct way to decipher the dynamics of a population’s responsiveness and diagnosis of a disease (Metcalf et al., 2016). Read more »

Treatment options of lethal Anaphylaxis, allergic Rhinitis & Asthma

The previous articles shed light on the prevalence of allergic diseases across five different geographic locations. Thus showing allergies to be a global problem and exerts considerable socioeconomic burden on the respective nations. Allergic diseases like Anaphylaxis, Rhinitis and Asthma interfere with day to day activities of an individual, resulting in physical and emotional distress. Read more »

Cost of treatment care for allergic disorders

The discussions on allergic disorders till now emphasized on the prevalence and severity, besides highlighting the significant treatment options. Henceforth, it is essential to discuss the economics associated with the different treatment options. This demands the exploration of the cost of illness also known as the burden of disease. Read more »

Role of phytoremediation in treating heavy metal pollution

In the previous article, the role of genetic engineering in improving bioremediation were discussed. With rapid industrialization, heavy metal contamination and organic pollutants have increasingly affected soil and water bodies. These threaten the ecosystem, surface and ground waters, food and human health. Phytoremediation is a method which involves growing plants in a contaminated matrix to remove environmental contaminants. Read more »

Gene ontology and gene interaction studies of Arabidopsis Thaliana

The previous article discussed the role of gene ontology in bioremediation. It also studied its importance in identifying new genes or proteins involved in bioremediation. Gene ontology can help in annotating and identifying important genes and proteins of organisms capable of bioremediation. Gene ontology analysis can assist in phytoremediation studies to mitigate dangerous pollutants. Read more »

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