Category: Biology »

Importance of lipoprotein in detecting cardiovascular diseases

Cardiovascular diseases are caused by a condition known as atherosclerosis. In this, a substance called plaque builds up in the walls of arteries, making them narrow and restricting the blood flow which leads to heart attack or stroke. The plaque formation occurs due to the buildup of cholesterol in the blood vessels. This happens when the low density lipoprotein (LDL) carrying the cholesterol to the cells enters the inner lining of blood vessels and are trapped in the artery walls. Read more »

Technologies and resources used in biomarker discovery and development

Biomarker development has served as an indicator of disease progression and response to therapeutic intervention. The conventional approach involved the study of molecules (considered as biomarker) in regulatory pathways but with the advent of technologies and resources, the development and biomarker discovery gotten easier (Tong & Li, 2016). Read more »

Application of Biomarkers in personalized medicine

The concept of personalized medicine was first promoted with pharmacogenomics data on oncology trials which demonstrated subject’s unique genetic makeup (genome) influence on their response to medications (The Office of the Commissioner FDA, 2015). Treatment biomarkers comprise of genes or a DNA sequence or an RNA strand which expresses uniquely in every individual. Read more »

Classification and application of different biomarkers

Biomarkers are any substance of biological origin, which is used as an indicator for certain medical conditions. Atkinson et al., (2001) defined the biomarker as:

“A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention”.

The assessment stated that a factual biomarker definition includes almost any measurement imitating an interaction between a potential hazard (biological, chemical or physical) and a biological system. The response of biomarkers measure functional and cellular level physiological, biochemical or a molecular interaction. Read more »

Emerging role of Bio marker in healthcare and medical sector

A bio marker or biological marker, are defined as an indicator of a biological state of a living body. It is a characteristic that is measured and evaluated as an indicator of normal biological processes. In addition, they also help in pathogenic processes or pharmacologic responses to a therapeutic intervention. Read more »

Global prevalence and distribution of cardiovascular diseases

Cardiovascular diseases (CVD) refers to a diverse range of conditions that affect the heart or blood vessels. Major types of CVDs’ include coronary heart disease, stroke and heart failure. CVDs’, still remain the major cause of death across all the regions of the world. In 2015, approximately 17.7 million people died across the globe due to CVDs’, which represents 31% of total global deaths (WHO, 2017). The established risk factors associated with CVDs’ are obesity, hypertension, diabetes, high cholesterol and smoking (Laslett et al., 2012). Read more »

Identification of common pipeline for biomarker discovery

As discussed in the previous article the biomarkers are any substance of biological origin, which is used as an indicator for certain medical condition within the biological system. Biomarker discovery comprises of a process of discovering biomarkers and is a multistep process that leads to clinical applications. Read more »

The importance of benchmarking in biomarker discovery and validation

Benchmarking is a process of comparing and contrasting best existing methods to new emerging techniques and methodologies. Benchmarking in biomarker discovery is a method of setting a baseline for identification and classification of new protein and molecules profiling technologies. Biomarkers are the best aid in understanding the cause, progression, diagnosis, regression and outcome of treatment of a disease. A number of biomarkers are currently very popular in diagnosis and management of cardiovascular diseases, infections, immunological and genetic disorders as well as in cancer (Perera and Weinstein, 2000). Read more »

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