Articles related to Importance of Molecular Biomarkers in Non-communicable diseases

Importance of machine learning in biomarker research

Increase in biological databases has escalated, so has the requirement for modern and powerful data analysis tools and techniques. To meet the demand, machine learning has become an indispensable tool in bioinformatics research. Biomarkers act as indicators of any biological state of the body. It can help to detect different kinds of diseases. Read more »

Serological and molecular marker analysis in infectious disease identification

Molecular markers are specific short sequences of DNA. They are capable of detecting polymorphism in unique chromosomal locations and can be random too. On the other hand, serological markers are used to quantify the concentrations of an antibody. Moreover, they are potentially the most direct way to understand the dynamics of a population. They are also popularly used in the diagnosis of a disease (Metcalf et al., 2016). The differences between alleles are traced as molecular markers. Here ‘alleles’ are defined as alternative forms of genes arising due to mutations. They help in identifying the desired gene or trait (Gupta et al., 2016). Therefore, serological and molecular marker analysis helps in the identification of different alleles or genes responsible for the identification of specific EIDs. Read more »

Genetic biomarker of peripheral arterial disease (PAD)

An atherosclerotic vascular disease that affects the blood vessels other than those in the coronary circulation, commonly known as the peripheral arterial disease (PAD) (Espinola-Klein, 2011). PAD is a complex disorder that is associated with multiple risk factors like ageing, smoking, diabetes mellitus, dyslipidemia, and hypertension (Krishna, Moxon and Golledge, 2015). However, there are reports showing the role of inflammation in the development and progression of atherosclerosis, eventually leading to PAD (Libby, Ridker, and Hansson, 2009).  Read more »

Role of biomarkers in cancer research and treatment

Biomarkers are referred to as any substance, structure or process that can be analyzed in the body and helps in predicting disease. Biomarkers have a crucial role in the early detection, diagnosis, and management of treatment for major diseases like cancer and heart diseases. This article presents the role of biomarkers in cancer research and treatment. Read more »

Importance of Micro RNA (miRNA) in lung cancer diagnosis and treatment

Micro RNA (miRNA) is 22 nucleotides long, single-stranded RNA molecules which play a crucial role in regulating the gene expression by translational repression. Micro RNA are found in abundance in both plants and animals. Micro RNA are non-coding in nature and are found to be evolutionarily conserved in nature. There is evidence that micro RNA have various roles in the development and progression of lung cancer. Read more »

How to use DAVID for functional annotation in Biomarker studies?

The database for annotation, visualisation and integrated discovery (DAVID) is a bioinformatics tool that consists of an integrated biological database and analytical tools. It helps to analyse large gene or protein sequences to extract meaningful information. DAVID provides a high throughput data mining environment. It helps to analyse the gene lists that are a result of high throughput genomic experiment (Huang, Sherman, & Lempicki, 2009). Read more »

Importance of Colorectal cancer biomarkers in epigenetic alterations

Both genetic and epigenetic alterations can cause Colorectal cancer (Voyias, Patel and Arasaradnam, 2016). Epigenetic modifications are those direct DNA modifications that influence non-coding RNAs like DNA methylation, histone modification, and chromatin remodelling. The increase in research in the area of biomarkers has improvement in diagnosis, prognosis, and prediction of treatment response in the patients with colorectal cancer. This article presents the emerging roles of epigenetic modifications in the detection, prognosis, and prediction of treatment response for colorectal cancer. Read more »

Genes involved in risk prediction of Ischemic stroke

Stroke has become a major health problem across the world, they are divided into two main types, ischemic stroke and hemorrhagic stroke. Ischemic stroke occurs as a result of the disturbance in the blood supply to the brain, often due to blockage in one of the arteries that leads to the brain. The underlying condition for this interruption in the development of lipid deposits that line the walls of the blood vessels. This condition is also known as “atherosclerosis.” Read more »

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