Biomarker identification based on hypothesis approach uses mechanistic realization of the disease processes. In contrast, discovery based methods have emphasized on recognizing changes in the relative abundance or presence of molecular species (McDermott et al., 2013).
Benchmarking is a process of comparing and contrasting best existing methods to new emerging techniques and methodologies. Benchmarking in biomarker discovery is a method of setting a baseline for identification and classification of new protein and molecules profiling technologies.
Cancer is the abnormal growth of cells that spread to other parts of the body via metastases. It has been a topic of research worldwide since the early 1960s. Since then it has had a great impact on human health and economies worldwide (Jemal et al., 2010).
UniProt is a protein database containing information on the TGFβ1 protein. In order to obtain relevant information, the researcher needs to type in keywords in the search tab as shown in the image below.
The CRISPR-Cas system is a form of genetic adaptive defence mechanism, found in bacteria and archaea, against invading nucleic acids and predatory viruses.