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The prevalence of different allergies has been explored in the previous articles across 5 case countries and comparisons have been drawn with prevalence in India. The findings implicate that incidence of several allergic responses have been rising continuously mainly due to development in technology and increase in severe pollution. Allergic reactions in present times are affecting nearly 20-30% of the Indian population. Allergy has become a cause of concern for both individuals and government. This is because of its social and economic impact in terms of cost of healthcare, loss of working hours and lower quality of life among others. This article explores the social and economic burden of allergic diseases in India.
In order to understand the process of using National Center for Biotechnology Information (NCBI) for extraction of gene information for bioinformatics studies, the author uses case example of Transforming Growth Factor beta 1 (TGFβ1) gene which encodes for the TGFB1 protein found in humans. Transforming growth factor beta 1 or TGF-β1 is a polypeptide and therefore belongs to the superfamily of cytokines (Ciftci et al., 2014). It has many cellular functions, such as cell growth, cell proliferation, cell differentiation and apoptosis (Jackowska et al., 2013).
As discussed in the previous article, workspace is a space wherein the variables used and created in a study are displayed. The variables can also be imported from data files or other programs. This article explains the process of adding variables to MATLAB and assigning values to those variables.
Matrix Laboratoryn (MATLAB) is a high-level language that is matrix based and includes an interactive environment for numerical computation, visualization,development and programming which was originally written in FROTRAN (Formual Translation). The present module is based on R 2017a version and is available for 64 bit Windows, Mac and Linux operating system. All the MATLAB variables used in MATLAB are stored in form of array. This article will explain the basic MATLAB interface and its useful tools.
UniProt is a protein database containing information on the TGFβ1 protein. In order to obtain relevant information, the researcher needs to type in keywords in the search tab as shown in the image below. After clicking the entry link i.e. P01137 (entry id), a new page will open. Read more »
In the previous article Drug related hypersensitivity, prevalence, diagnosis and therapeutic considerations, we discussed about how different drugs lead to different allergic responses. However, it is important that mechanism of different drug is studied which leads to ADR. In the present article Abacavir, a drug which is used for the treatment and prevention of Human Immuno Deficiency Virus (HIV) (Hewitt et al., 2002) is being discussed. Abacavir is a synthetic carbocyclic nucleoside which is categorised under the class of Nucleoside Reverse Transcriptase Inhibitors. Read more »